{"id":2475,"date":"2014-03-27T11:25:50","date_gmt":"2014-03-27T03:25:50","guid":{"rendered":"http:\/\/www.leadingtec.cn\/?p=2475"},"modified":"2014-04-11T17:15:31","modified_gmt":"2014-04-11T09:15:31","slug":"algae-anti-cancer","status":"publish","type":"post","link":"https:\/\/www.leadingtec.cn\/algae-anti-cancer.html","title":{"rendered":"\u85fb\u7c7b\u6297\u80bf\u7624\u6d3b\u6027\u7269\u8d28\u7684\u7814\u7a76"},"content":{"rendered":"

\u672c\u6587\u7efc\u8ff0\u4e86\u8fd110\u5e74\u6765\u56fd\u5185\u5916\u62a5\u9053\u768426\u79cd\u5fae\u85fb\u548c34\u79cd\u5927\u578b\u85fb\u7684\u6297\u80bf\u7624\u6d3b\u6027\u4ee5\u53ca\u76f8\u5e94\u6d3b\u6027\u5316\u5408\u7269\u7684\u7ed3\u6784\uff0c\u5bf9\u5176\u4e2d\u8f83\u91cd\u8981\u8005\u7684\u4f5c\u7528\u673a\u7406\u4f5c\u4e86\u8f83\u8be6\u7ec6\u7684\u4ecb\u7ecd\uff0c\u5e76\u5c31\u6211\u56fd\u85fb\u7c7b\u6297\u80bf\u7624\u6d3b\u6027\u7684\u7814\u7a76\u73b0\u72b6\u53ca\u53d1\u5c55\u63d0\u51fa\u4e86\u5efa\u8bbe\u6027\u610f\u89c1\u3002\"\"<\/span><\/p>\n

\n

\u5728\u5929\u7136\u836f\u7269\u7814\u7a76\u4e2d\u6297\u80bf\u7624\u6d3b\u6027\u4e00\u76f4\u662f\u6700\u4e3a\u91cd\u8981\u7684\u7814\u7a76\u9886\u57df\uff0c\u4ece\u85fb\u7c7b\u4e2d\u53d1\u73b0\u8fd9\u7c7b\u6d3b\u6027\u7269\u8d28\u5360\u6709\u91cd\u8981\u7684\u5730\u4f4d\uff0c\u56e0\u4e3a\u85fb\u7c7b\u591a\u53d8\u7684\u751f\u6d3b\u73af\u5883\u548c\u539f\u59cb\u7684\u8fdb\u5316\u5730\u4f4d\u4f7f\u5176\u62e5\u6709\u8bb8\u591a\u7ed3\u6784\u65b0\u9896\u7684\u6d3b\u6027\u7269\u8d28\u3002\u56fd\u5916\u5bf9\u5176\u7814\u7a76\u59cb\u4e8e50\u5e74\u4ee3\u53d1\u73b0\u5de8\u5927\u9798\u4e1d\u85fb\u7684\u8102\u6eb6\u6027\u63d0\u53d6\u7269\u5177\u6709\u6297\u767d\u8840\u75c5\u6d3b\u6027\uff0c\u4ece\u800c\u6fc0\u8d77\u4e86\u5bf9\u85fb\u7c7b\u6297\u80bf\u7624\u6d3b\u6027\u7814\u7a76\u7684\u5174\u8da3\u3002\u4ece\u9ed1\u6d77\u85fb\u4e2d\u53d1\u73b0\u8bb8\u591a\u6709\u6297\u80bf\u7624\u6f5c\u529b\u7684\u85fb\u79cd\uff0c\u6709\u949d\u5f62\u51f9\u9876\u85fb\uff08Laurencia obtusa\uff09\u3001\u7f51\u5730\u85fb\uff08Dictyota dichotoma\uff09\u3001\u56ca\u53f6\u85fb\uff08Cystoseira crinita Cystoseira barbata\uff09\u3001\u77f3\u83bc\uff08Ulva rigida\uff09\u3001\u7f18\u7ba1\u6d52\u82d4\uff08Enteromorpha linza\uff09\u3001\u521a\u6bdb\u85fb \uff08Cladphora sp.\uff09\u3001\u524d\u6c9f\u85fb\uff08Amphidinium\uff09\u3001\u5c0f\u7403\u85fb\uff08Chlorella pyrenoidosa\uff09\u3001\u9ccd\u85fb\uff08Dinophisis\uff09\u3001\u88f8\u7532\u85fb\uff08Gymnodinium\u3001Gyrodinium\uff09\u3001\u539f\u7532\u85fb\uff08Prorocentrum\uff09\u3001\u98a4\u85fb\uff08Oscillatoria\uff09\u3001\u87ba\u65cb\u85fb\uff08Spirulina\uff09\u7b49\uff3b1\uff3d<\/sup>\u3002Guven\u7b49\u5217\u51fa\u4e8614\u79cd\u7eff\u85fb\u300123\u79cd\u8910\u85fb\u300123\u79cd\u84dd\u85fb\u548c7\u79cd\u7ea2\u85fb\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\uff3b2\uff3d<\/sup>\u300280\u5e74\u4ee3\u521d\u7f8e\u65e5\u79d1\u5b66\u5bb6\u5f00\u59cb\u7cfb\u7edf\u7684\u7b5b\u9009\u84dd\u85fb\u53ca\u5176\u4ed6\u85fb\u7c7b\u7684\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u53d1\u73b0\u4e86\u8bb8\u591a\u65b0\u7684\u6d3b\u6027\u5316\u5408\u7269\uff0c\u5982\u4ece\u84dd\u85fb\u4e2d\u63d0\u53d6\u7684Scytophycin B\u5df2\u8fdb\u5165\u4e34\u5e8a\u9636\u6bb5\uff1b\u4ece\u677e\u9999\u85fb\u4e2d\u5206\u79bb\u7684Halomon\u76ee\u524d\u4e5f\u5df2\u8fdb\u5165\u4e34\u5e8a\u524d\u836f\u7406\u8bc4\u4f30\u9636\u6bb5\u3002\u5176\u4ed6\u4ece\u85fb\u7c7b\u4e2d\u5206\u79bb\u51fa\u6765\u6297\u80bf\u7624\u7269\u8d28\u5982Cryptophycin\u7b49\u5df2\u5b8c\u5168\u6e05\u695a\u4e86\u5176\u4f5c\u7528\u673a\u7406\u53ca\u836f\u7406\u6548\u5e94\uff1bMalyngamide\u7b49\u5df2\u6e05\u695a\u4e86\u7ed3\u6784\uff0c\u5b8c\u6210\u4e86\u6bd2\u7406\u5b9e\u9a8c\uff0c\u6b63\u5728\u8fdb\u884c\u6df1\u5165\u7684\u7814\u7a76\u3002<\/p>\n

\u968f\u7740\u5929\u7136\u836f\u7269\u7814\u7a76\u7684\u6df1\u5165\uff0c\u85fb\u7c7b\u4f5c\u4e3a\u4e00\u79cd\u91cd\u8981\u7684\u751f\u7269\u8d44\u6e90\u8d8a\u6765\u8d8a\u53d7\u5230\u91cd\u89c6\u3002\u7531\u4e8e\u85fb\u7c7b\u7684\u53ef\u518d\u751f\u6027\uff0c\u662f\u4e00\u79cd\u53d6\u4e4b\u4e0d\u5c3d\u7684\u836f\u6e90\u7269\u8d28\u3002\u73b0\u4ee3\u751f\u7269\u6280\u672f\u7684\u5e94\u7528\uff0c\u57fa\u672c\u4e0a\u89e3\u51b3\u4e86\u836f\u6e90\u85fb\u7c7b\u7684\u517b\u6b96\u95ee\u9898\uff0c\u4e3a\u85fb\u7c7b\u6297\u80bf\u7624\u7269\u8d28\u7684\u7814\u7a76\u63d0\u4f9b\u4e86\u5145\u8db3\u7684\u6750\u6599\u548c\u53ef\u80fd\u6027\u3002\u73b0\u4ee3\u5206\u79bb\u5206\u6790\u6280\u672f\u7684\u63d0\u9ad8\u548c\u9ad8\u901a\u91cf\u7b5b\u9009\u6280\u672f\u7684\u5e94\u7528\uff0c\u4f7f\u85fb\u7c7b\u6297\u80bf\u7624\u6d3b\u6027\u7269\u8d28\u7814\u7a76\u5f97\u4ee5\u98de\u901f\u53d1\u5c55\u3002\u672c\u6587\u62df\u5bf9\u85fb\u7c7b\u6297\u80bf\u7624\u7269\u8d28\u7684\u6d3b\u6027\u7b5b\u9009\u548c\u6d3b\u6027\u5316\u5408\u7269\u7814\u7a76\u8fdb\u5c55\u4f5c\u4e00\u7efc\u8ff0\u3002<\/p>\n

1\u3000\u5fae\u85fb\u6297\u80bf\u7624\u7269\u8d28\u7684\u6d3b\u6027\u7b5b\u9009\u53ca\u7ed3\u6784\u5206\u6790<\/strong><\/p>\n

\u5fae\u85fb\u4e3b\u8981\u5305\u62ec\u84dd\u85fb\u3001\u7532\u85fb\u3001\u91d1\u85fb\u548c\u5c11\u6570\u7eff\u85fb\u3002\u7531\u4e8e\u5176\u5206\u5e03\u5730\u57df\u5e7f\u3001\u4e2a\u4f53\u53d8\u5f02\u5927\u3001\u79cd\u7c7b\u7e41\u591a\u3001\u9002\u5e94\u591a\u53d8\u7684\u73af\u5883\u7b49\u7279\u70b9\uff0c\u4ece\u4e2d\u53d1\u73b0\u6297\u80bf\u7624\u7269\u8d28\u7684\u673a\u7387\u8f83\u5927\uff0c\u76ee\u524d\u5df2\u7ecf\u4ece\u4e2d\u53d1\u73b0\u4e86\u5f88\u591a\u91cd\u8981\u7684\u6d3b\u6027\u5316\u5408\u7269\u3002\u540c\u65f6\u7531\u4e8e\u751f\u7269\u53cd\u5e94\u5668\u3001\u7ec6\u80de\u57f9\u517b\u3001\u751f\u7269\u5de5\u7a0b\u7b49\u6280\u672f\u7684\u5e94\u7528\uff0c\u5fae\u85fb\u6297\u80bf\u7624\u7814\u7a76\u5728\u8fd1\u5e74\u5f97\u5230\u5f88\u5927\u7684\u53d1\u5c55\u3002<\/p>\n

\u590f\u5a01\u5937\u5927\u5b66\u7684Patterson\u7b49\u4ece1981\u5e74\u5f00\u59cb\uff0c\u4ece\u5927\u7ea6400\u79cd1500\u682a\u84dd\u85fb\u7684\u8102\u6eb6\u6027\u548c\u6c34\u6eb6\u6027\u63d0\u53d6\u7269\u4e2d\u7b5b\u9009\u751f\u7269\u6d3b\u6027\u7269\u8d28\uff0c\u53d1\u73b0\u5927\u7ea67%\u7684\u63d0\u53d6\u7269\u5177\u6709\u6291\u5236\u4eba\u9f3b\u54bd\u764cKB\u7ec6\u80de\u7cfb\u589e\u6b96\u7684\u6d3b\u6027\uff0c\u4ece\u4e2d\u5206\u79bb\u4e86\u4e00\u4e9b\u7ed3\u6784\u72ec\u7279\u3001\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\u7684\u7269\u8d28\uff3b3\uff3d<\/sup>\u3002Patterson\u7b49\u53d1\u73b05\u4e2a\u85fb\u79cd\u76847\u4e2a\u6837\u54c1\u7684\u63d0\u53d6\u7269\u5bf9\u5c0f\u9f20P388<\/sub>\u6dcb\u5df4\u767d\u8840\u75c5\u7684T\/C\u503c\u5927\u4e8e150%\uff0c\u5b83\u4eec\u662f\u591a\u53d8\u9c7c\u8165\u85fb(Anabaena variabilis)\u7684\u4e8c\u6c2f\u7532\u70f7\u6eb6\u6db2\uff1b\u5de8\u5927\u9798\u4e1d\u85fb(Lyngbya majuscula)\u7684\u6c34\u6eb6\u6db2\u3001\u5df2\u70f7\u6eb6\u6db2\u3001\u4e59\u9178\u4e59\u916f\u63d0\u53d6\u6db2\uff1b\u5ff5\u73e0\u85fb(Nostoc muscorum J. A. G.)\u7684\u6c34\u63d0\u53d6\u7269\uff1b\u98a4\u85fb(Oscillatoria sp.)\u7684\u6c34\u6eb6\u6db2\u4ee5\u53ca\u88d9\u5e26\u83dc(Undaria pinnatifida Sur.)\u768430%\u4e59\u9187\u63d0\u53d6\u7269\u3002\u98a4\u85fb(Oscillatoria sp.)\u7684\u6c34\u6eb6\u6db2\u548cn-\u4e01\u9187\u63d0\u53d6\u6db2\u8fd8\u80fd\u6709\u6548\u7684\u6291\u5236Ehrlich\u8179\u6c34\u7624\u3002<\/p>\n

\u4ece\u5b9a\u97ad\u91d1\u85fb\u7c7b\u63d0\u53d6\u7684\u6bd2\u7d20Prymnesin\u5bf9\u827e\u6c0f\u8179\u6c34\u7624\u7ec6\u80de\u5177\u6709\u7ec6\u80de\u6bd2\u6d3b\u6027\u3002\u524d\u6c9f\u85fb\uff08Amphidinium sp.\uff09\u4ea7\u751f\u7684\u5927\u73af\u5185\u916f\u7c7b\u7269\u8d28Amphidinolide A\uff0c\u5177\u6709\u4f53\u5916\u6297\u80bf\u7624\u6d3b\u6027\uff1bAmphidinolide B\u5bf9\u5c0f\u9f20L1210<\/sub>\u548cKB\u7ec6\u80de\u7684IC50<\/sub>\u4e3a0.14\u03bcg\u00b7L-1<\/sup>\u548c4.2\u03bcg\u00b7L-1<\/sup>\u3002\u4ece\u53e6\u4e00\u79cd\u524d\u6c9f\u85fb\u4e2d\u5206\u79bb\u51faAmphidinolide B\u548c\u4e00\u79cd\u65b0\u7684\u5177\u6709\u7ec6\u80de\u6bd2\u6d3b\u6027\u7684Amphidinolide D.<\/p>\n

\u4f2a\u679d\u85fb\u79d1(Scytonemataceae)\u548c\u771f\u679d\u85fb\u79d1(Stigonemataceae)\u7684\u8bb8\u591a\u79cd\u7c7b\u7684\u63d0\u53d6\u7269\u5177\u6709\u6297\u80bf\u7624\u4f5c\u7528\uff3b3\u30014\uff3d<\/sup>\u3002\u4f2a\u679d\u85fb(Scytonema pseudohofmanni)\u4ea7\u751f\u7684\u591a\u80bd\u7c7b\u5927\u73af\u5185\u916f\u5316\u5408\u7269Scytophycin B(\u56fe1)<\/p>\n

\"151901\"<\/a> Fig 1\u3000Scytophycin B<\/p>\n

\u5bf9\u4eba\u7c7b\u9f3b\u54bd\u764cKB\u7ec6\u80de\u3001\u5927\u9f20\u8179\u819c\u5185\u7684P<\/span>388<\/sub>\u6dcb\u5df4\u767d\u8840\u75c5\u7ec6\u80de\u548cLewis\u80ba\u764c\u7ec6\u80de\u5177\u6709\u8f83\u5f3a\u7684\u7ec6\u80de\u6bd2\u6d3b\u6027\u3002Scytophycin\u662f\u4e00\u79cd\u6709\u6548\u7684\u5fae\u7ba1\u89e3\u805a\u5242\uff0c\u5b83\u901a\u8fc7\u963b\u6b62P\u7403\u86cb\u767d\u7684\u5f62\u6210\u6709\u6548\u5730\u6291\u5236\u80bf\u7624\u7ec6\u80de\u7684\u589e\u6b96<\/span>\uff3b5\uff3d<\/sup>\u3002\u7b52\u5b62\u85fb\uff08Cylindrospernum sp.\uff09\u7684\u67d0\u4e9b\u85fb\u682a\u4e5f\u80fd\u4ea7\u751fScytophycin B\u3001Scytophycin E\u7b49\uff0c\u5176\u5bf9KB\u7ec6\u80de\u7684IC<\/span>50<\/sub>\uff1d2\uff5e10mg\u00b7L<\/span>-1\uff3b6\uff3d<\/sup>\u3002<\/span><\/p>\n

\u4ece\u5947\u5f02\u4f2a\u679d\u85fb(S.mirabile)\u548c\u5355\u679d\u6b67\u85fb(Tolypothrix conglutinata var.)\u4e2d\u63d0\u53d6\u7684Tolytoxin\u5177\u6709\u4e0eScytophycin B\u7c7b\u4f3c\u7684\u6d3b\u6027\u3002\u5728NCI\u7684\u6bd4\u8f83\u751f\u7269\u8bd5\u9a8c\u4e2d\u663e\u793a\u5f88\u5f3a\u7684\u9009\u62e9\u6027\u6297\u80bf\u7624\u6d3b\u6027\u3002Tolytoxin\u80fd\u6709\u6548\u5730\u5e72\u6270\u673a\u4f53\u7684\u5fae\u4e1d\u5f62\u6210\uff0c\u5bfc\u81f4\u771f\u6838\u7ec6\u80de\u65e0\u6cd5\u5f62\u6210\u7ec6\u80de\u751f\u957f\u6240\u9700\u8981\u7684\u6536\u7f29\u73af\uff0c\u5176\u5bf9\u5404\u79cd\u4eba\u4f53\u80bf\u7624\u7ec6\u80de\u7cfb\u7684IC50<\/sub>\u4e3a0.52\uff5e8nmol\u00b7L-1\uff3b7\uff3d<\/sup>\u3002<\/p>\n

\u4ece\u5947\u5f02\u4f2a\u679d\u85fb(S.mirabile BY-8-1)\u85fb\u682a\u4e2d\u5206\u79bb\u51fa38\u79cd\u751f\u7269\u6d3b\u6027\u7269\u8d28\uff0c\u5206\u4e3a4\u7c7b\u4e0d\u540c\u7ed3\u6784\u7684\u5316\u5408\u7269\uff1a\u5927\u73af\u5185\u916f\u5316\u5408\u72693\u79cd\uff1b\u5f02\u6c30\u7c7b\u5316\u5408\u72696\u79cd(mirablene isonitriles A-F)\uff0c\u5b83\u4eec\u5bf9KB\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u5242\u91cf\u4e3a1\uff5e10mg\u00b7L-1<\/sup>\uff1b\u4e9a\u80fa\u7c7b\u5316\u5408\u72695\u79cd(mirabimides A-E)\uff0c\u5b83\u4eec\u5bf9KB\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u5242\u91cf\u4e3a5\uff5e10mg\u00b7L-1<\/sup>,\u4ee5\u53ca\u5927\u7ea624\u79cd\u4fee\u9970\u591a\u80bd\uff0c\u5982Tantazole B\uff0c\u5b83\u4eec\u5bf9KB\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u5242\u91cf\u4e3a0.01\uff5e10mg\u00b7L-1<\/sup>\u3002\u4ece\u4f2a\u679d\u85fb\uff08S. burmanicum\uff09\u548c\u773c\u70b9\u4f2a\u679d\u85fb\uff08S. ocellatum\uff09\u4e2d\u4e5f\u53d1\u73b0\u591a\u79cd\u4f2a\u679d\u85fb\u7c7b\u7684\u6bd2\u7d20\uff3b4\uff3d<\/sup>\u3002<\/p>\n

\"151902\"<\/a><\/p>\n

Fig 2\u3000 Malyngamide D<\/p>\n

Malyngamide D(\u56fe2)\u662f\u5de8\u5927\u9798\u4e1d\u85fb(L.majuscula)\u7684\u6b21\u7ea7\u4ee3\u8c22\u7269\uff0c\u5bf9KB\u7ec6\u80de\u6709\u7ec6\u80de\u6bd2\u6d3b\u6027\uff0c\u5176IC50<\/sub>\uff1c30mg\u00b7g-1<\/sup>\u3002\u4ece\u4e00\u79cd\u5de8\u5927\u9798\u4e1d\u85fb(L. majuscula)\u4e2d\u5206\u79bb\u51fa\u4e24\u79cd\u65b0\u578b\u7684\u514d\u75ab\u6291\u5236\u80bdMicrocolins A\u3001B\uff0c\u5728\u4f53\u5916\u6709\u660e\u663e\u7684\u6297\u5c0f\u9f20P388<\/sub>\u767d\u8840\u75c5\u7ec6\u80de\u6d3b\u6027\uff0c\u5176IC50<\/sub>\uff1d0.4mg\u00b7L-1<\/sup>\u3002\u4ece\u5de8\u5927\u9798\u4e1d\u85fb\u7684\u6df1\u6c34\u53d8\u79cd\u4e2d\u5206\u79bb\u7684\u9798\u4e1d\u85fb\u6bd2\u7d20A(Lyngbyatoxin A)\uff0c\u5bf9\u5c0f\u9f20P388<\/sub>\u767d\u8840\u75c5\u7ec6\u80de\u6709\u6291\u5236\u4f5c\u7528\u3002\u4ece\u5de8\u5927\u9798\u4e1d\u85fb\u4e2d\u8fd8\u53d1\u73b0Lyngbyastatin 2\u3001Lyngbyatoxins B\u3001Lyngbyatoxins C\u7b49\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u7269\u8d28\uff3b8\uff3d<\/sup>\uff0c\u53bb\u6eb4\u6d77\u5154\u6bd2\u7d20(Debromoaplysiatoxin)\u7684\u771f\u6b63\u6765\u6e90\u4e5f\u662f\u5de8\u5927\u9798\u4e1d\u85fb\uff0c\u6b64\u6bd2\u7d20\u5bf9P388<\/sub>\u767d\u8840\u75c5\u6709\u4e00\u5b9a\u6548\u679c\uff3b9\uff3d<\/sup>\u3002<\/p>\n

\"151903\"<\/a><\/p>\n

Fig 3\u3000 Hormothamnione A<\/p>\n

Hormothamnione A(\u56fe3)\u662f\u4ece\u6d77\u6d0b\u84dd\u85fbChrysophaeum taylori\u4e2d\u63d0\u53d6\u7684\uff0c\u5b83\u5bf9P388<\/sub>\u6dcb\u5df4\u767d\u7ec6\u80de\u548cHL-60\u65e9\u5e7c\u7c92\u767d\u8840\u75c5\u7ec6\u80de\u90fd\u6709\u7ec6\u80de\u6bd2\u4f5c\u7528\uff0c\u5176IC50<\/sub>\u5206\u522b\u662f4.6\u03bcg\u00b7L-1<\/sup>\u548c0.1\u03bcg\u00b7L-1\uff3b9\uff3d<\/sup>\u3002\u4eceChrysophaeum taylori\u8fd8\u5206\u79bb\u51fa\u4e00\u79cd\u65b0\u7684\u7ec6\u80de\u6bd2\u6d3b\u6027\u76846-Desmethoxyhor-moth-amnione\u3002\u4ece\u4e00\u79cd\u91d1\u85fb\u4e2d\u4e5f\u5206\u79bb\u51fa\u4e86Hormothamnione A\uff0c\u5e76\u5177\u6709\u540c\u6837\u7684\u6d3b\u6027\u3002<\/p>\n

\"151904\"<\/a><\/p>\n

Fig 4\u3000 Cryptophycins<\/p>\n

Cryptophycins(\u56fe4)\u662f\u4ece\u5ff5\u73e0\u85fb(Nostoc sp. strain GSV 224)\u4e2d\u63d0\u53d6\u7684\u591a\u80bd\uff0c\u5bf9\u5c0f\u9f20\u5f02\u79cd\u79fb\u690d\u7684\u4e73\u764c\u3001\u5375\u5de2\u764c\u3001\u514b\u9686\u764c\u3001\u80f0\u817a\u764c\u5177\u6709\u5f3a\u7684\u6d3b\u6027\uff0c\u5176\u4f5c\u7528\u673a\u7406\u662f\u901a\u8fc7\u5f15\u8d77\u5fae\u4e1d\u7684\u89e3\u805a\u4f5c\u7528\u800c\u963b\u788d\u7ec6\u80de\u5468\u671f\u7684G2<\/sub> \/M\u671f\u3002\u4ece\u5ff5\u73e0\u85fb(Nostoc sp.)\u4f53\u5185\u5206\u79bb\u51fa7\u4e2aCryptophycins,\u5176\u4e2dCryptophcycinl\u5177\u6709\u4e3b\u8981\u7684\u7ec6\u80de\u6bd2\u6d3b\u6027\uff0c\u5b83\u62e5\u6709\u4e00\u6c2fL-O-\u7532\u57fa\u916a\u6c28\u9178\u5355\u5143\u3002Cryptophycin 2\uff5e7\u6709\u8f83\u5f31\u7684\u6d3b\u6027\u3002\u4f53\u5185\u7814\u7a76\u8868\u660e\u5929\u7136\u7684Cryptophycins1\u548c\u534a\u5408\u6210\u7684Cryptophycins 8\u5bf9\u8bb8\u591a\u79fb\u690d\u7624\u5305\u62ec\u591a\u836f\u7269\u6297\u6027(Multidrug Resistance,MDR)\u7ec6\u80de\u7cfb\u5177\u6709\u6d3b\u6027\uff0c\u5e76\u4e14\u6709\u8f83\u597d\u7684\u6c34\u6eb6\u6027\u548c\u6cbb\u7597\u6548\u679c\uff0c\u800cMDR\u662f\u5f71\u54cd\u80bf\u7624\u5316\u7597\u6548\u679c\u7684\u4e00\u4e2a\u975e\u5e38\u91cd\u8981\u7684\u56e0\u7d20\uff0c\u5b83\u9884\u793aCryptophycins\u5f88\u6709\u53ef\u80fd\u6210\u4e3a\u4e34\u5e8a\u836f\u7269\uff3b10\u300111\uff3d<\/sup><\/p>\n

\"151905\"<\/a><\/p>\n

Fig 5\u3000Okadaic acid<\/p>\n

\u5927\u7530\u8f6f\u6d77\u7ef5\u9178Okadaic acid(\u56fe5)\u57285\u03bcg\u00b7g-1<\/sup>\u7684\u6d53\u5ea6\u80fd\u6291\u523680%\u7684KB\u7ec6\u80de\u7684\u751f\u957f\u3002\u5b83\u6700\u521d\u662f\u4ece\u6d77\u7ef5Halichondria odadai\u4e2d\u5206\u79bb\u51fa\u6765\u7684\uff0c\u540e\u6765\u8bc1\u660e\u662f\u6d77\u6d0b\u539f\u7532\u85fb(Prorocentrum lima)\u7684\u6b21\u7ea7\u5206\u6ccc\u7269\uff0c\u5e76\u4e14\u53ef\u4ee5\u901a\u8fc7\u4eba\u5de5\u57f9\u517b\u539f\u7532\u85fb\u6765\u63d0\u53d6\u3002Okadaic acid\u662f\u4e5f\u4e00\u4e2a\u80bf\u7624\u4fc3\u8fdb\u5242\uff0c\u8fd8\u80fd\u6291\u5236\u7531\u9499\u6fc0\u6d3b\u7684\u78f7\u8102\u4f9d\u8d56\u7684\u86cb\u767d\u6fc0\u9176\uff0c\u4ee5\u53ca\u4f53\u5916\u6291\u5236\u86cb\u767d\u8d28\u78f7\u9178\u9176-1\u548c\u86cb\u767d\u8d28\u78f7\u9178\u9176-2A\u3002Haystead \u8fdb\u4e00\u6b65\u8bc1\u660eOkadaic acid\u80fd\u5728\u5b8c\u6574\u7684\u7ec6\u80de\u5185\u8fc5\u901f\u523a\u6fc0\u86cb\u767d\u8d28\u78f7\u9178\u5316\uff0c\u5176\u884c\u4e3a\u5728\u5404\u79cd\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u7c7b\u4f3c\u86cb\u767d\u8d28\u78f7\u9178\u9176\u6291\u5236\u5242\uff3b12\u300113\uff3d<\/sup>\u3002<\/p>\n

\u6587\u732e\u62a5\u9053\u87ba\u65cb\u85fb\u4e5f\u6709\u6297\u7624\u7684\u4f5c\u7528\uff0c\u87ba\u65cb\u85fb\u6d53\u5ea6\u4e3a100\u03bcg\u00b7L-1<\/sup>\u65f6\u5bf9\u80bf\u7624\u7ec6\u80de\u7cfbBcap-37\u548cHeLa\u7ec6\u80de\u6709\u6291\u5236\u548c\u81f4\u6b7b\u4f5c\u7528\uff0c\u540c\u6837\u6761\u4ef6\u4e0b\u5bf9\u6b63\u5e382BS\u7ec6\u80de\u65e0\u5f71\u54cd\uff3b14\uff3d<\/sup>\u3002\u5176\u4ed6\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\u7684\u7269\u8d28\u53ca\u5fae\u85fb\u7c7b\u540d\u79f0\u89c1\u88681\u3002<\/p>\n

\u88681\u3000\u5fae\u85fb\u4e2d\u7684\u6297\u80bf\u7624\u6d3b\u6027\u6210\u5206<\/p>\n

Table 1 Antitumor activity materials in microalgae<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\u85fb\u79cd<\/td>\n\u6d3b\u6027\u7269\u8d28<\/td>\n\u751f\u7269\u6d3b\u6027<\/td>\n\u6587\u732e\u6765\u6e90<\/td>\n<\/tr>\n
Oscillatoria<\/td>\nAcutiphycins<\/td>\n\u7ec6\u80de\u6bd2\u6d3b\u6027<\/td>\nBarchi,1984<\/td>\n<\/tr>\n
Nostoc<\/td>\nIndolocarbazoles<\/td>\n\u7ec6\u80de\u6bd2\u6d3b\u6027<\/td>\nKnubel,1990<\/td>\n<\/tr>\n
Scytonema<\/td>\nMirablene Isonitriles<\/td>\nKB\u7ec6\u80de<\/td>\nCarmeli,1990<\/td>\n<\/tr>\n
Cylindrospermum Nostoc<\/td>\nParacyclophanes<\/td>\n\u7ec6\u80de\u6bd2\u6d3b\u6027<\/td>\nMoore,1990<\/td>\n<\/tr>\n
Scytonema, Tolypothrix sp<\/td>\nScytophycins<\/td>\n\u7ec6\u80de\u6bd2\u548c\u6297\u771f\u83cc<\/td>\nIshibashi,1986;Carmeli,1990;Jung,1991<\/td>\n<\/tr>\n
Tolypothrix<\/td>\nToyocamycin-5-alpha-D-glucopyranose;Toyocamycin<\/td>\n\u7ec6\u80de\u6bd2\u6d3b\u6027<\/td>\nStewart,1988<\/td>\n<\/tr>\n
Plectonema;Scytonema;<\/td>\nTubercidin<\/td>\n\u7ec6\u80de\u6bd2\u6d3b\u6027<\/td>\nStewart,1988<\/td>\n<\/tr>\n
Tolypothrix<\/td>\nTubercidin-5-alpha-D-glucopyranose<\/td>\n\u7ec6\u80de\u6bd2\u6d3b\u6027<\/td>\nStewart,1988<\/td>\n<\/tr>\n
Hormothamnion enteromorphoides<\/td>\nhormothamnin A<\/td>\nP388<\/sub>\u3001HL60<\/sub>\u3001\u6297\u5fae\u751f\u7269\u6d3b\u6027<\/td>\nGerwick,1992<\/td>\n<\/tr>\n
Hormidium. enteromorphoides<\/td>\n\u7279\u6b8a\u591a\u80bd<\/td>\n\u7ec6\u80de\u6bd2\u6d3b\u6027<\/td>\nGerwick,1989<\/td>\n<\/tr>\n
Phormidium sp.<\/td>\n\u7532\u9187\u63d0\u53d6\u7269<\/td>\n\u6297\u6dcb\u5df4\u767d\u8840\u75c5\uff0cEhrlich\u8179\u6c34\u7624<\/td>\nMundt,1988<\/td>\n<\/tr>\n
Westiellopsis prolifica<\/td>\nWestiellamide<\/td>\nKB\u7ec6\u80deLoVo\u7ec6\u80de<\/td>\nHambley,1992<\/td>\n<\/tr>\n
Chorella vugari<\/td>\n\u8010\u9ad8\u6e29\u7684\u7403\u86cb\u767d<\/td>\n\u6297\u80bf\u7624<\/td>\nMatsueda,1988<\/td>\n<\/tr>\n
Chlorella vugari<\/td>\n\u5355\u534a\u4e73\u7cd6\u57fa\u4e8c\u9170\u57fa<\/td>\n\u6297\u80bf\u7624\u53d1\u751f<\/td>\nMorimoto,1995<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

2\u3000\u5927\u578b\u85fb\u6297\u80bf\u7624\u7269\u8d28\u7684\u6d3b\u6027\u7b5b\u9009\u53ca\u7ed3\u6784\u5206\u6790<\/strong><\/p>\n

\u5927\u578b\u85fb\u4e3b\u8981\u5305\u62ec\u7ea2\u85fb\u3001\u8910\u85fb\u548c\u7eff\u85fb\u3002\u5927\u578b\u85fb\u5728\u81ea\u7136\u754c\u5206\u5e03\u8f83\u5e7f\uff0c\u79cd\u7c7b\u7e41\u591a\uff0c\u540c\u65f6\u7531\u4e8e\u5176\u4e2a\u4f53\u8f83\u5927\uff0c\u6709\u4e9b\u79cd\u7c7b\u5df2\u7ecf\u4eba\u5de5\u517b\u6b96\uff0c\u5bb9\u6613\u53d6\u5f97\u8db3\u591f\u7684\u6837\u54c1\uff0c\u662f\u6c34\u751f\u751f\u7269\u4e2d\u6700\u91cd\u8981\u7684\u518d\u751f\u8d44\u6e90\uff0c\u56e0\u6b64\u4e5f\u5438\u5f15\u4e86\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8005\u3002 <\/span><\/p>\n

Harada\u7b49\u5bf9\u65e5\u672c\u6cbf\u6d77\u7684306\u79cd\u6d77\u85fb\u76841446\u4e2a\u6837\u54c1\u7684\u4f53\u5916\u6297\u80bf\u7624\u6d3b\u6027\u8fdb\u884c\u4e86\u68c0\u6d4b\u548c\u7b5b\u9009\uff0c\u53d1\u73b093\u79cd\u8910\u85fb\u4e2d\u768436\u79cd\u3001151\u79cd\u7ea2\u85fb\u4e2d\u768430\u79cd\u300151\u79cd\u7eff\u85fb\u4e2d\u76844\u79cd\u5177\u6709\u5bf9\u5c0f\u9f20\u6dcb\u5df4\u767d\u8840\u75c5\u7684\u7ec6\u80de\u6bd2\u6d3b\u6027\uff0c\u5176\u4e2d\u670910\u79cd\u6709\u9009\u62e9\u6027\u6740\u706d\u764c\u7ec6\u80de\u7684\u4f5c\u7528\uff0c\u67094\u79cd\u5bf9L<\/span>1210<\/sub>\u7ec6\u80de\u6709\u5f88\u5f3a\u6bd2\u6027\uff0c\u800c\u5bf9\u6b63\u5e38\u7ec6\u80de\u6d3b\u6027\u8f83\u5c0f\u3002\u5176\u4e2d\u62df\u521a\u6bdb\u85fb(Cladophoropsis vaucherinaformis)\u7684\u7532\u9187\u63d0\u53d6\u7269\u5bf9L<\/span>1210<\/sub>\u7ec6\u80de\u6709\u6700\u5f3a\u7684\u9009\u62e9\u6027\u6291\u5236\u4f5c\u7528\uff0c\u5bf986%\u7684\u6b63\u5e38\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u4e0d\u660e\u663e\uff0c\u5b9e\u9a8c\u8fd8\u8bc1\u660e\u7532\u9187\u63d0\u53d6\u7269\u53ea\u5bf9L<\/span>1210<\/sub>\u548cP<\/span>388<\/sub>\u8d77\u4f5c\u7528\u3002\u5176\u8d77\u4f5c\u7528\u7684\u6d53\u5ea6\u4e3a50\uff5e100\u03bc\u00b7L<\/span>-1<\/sup>\uff0c\u572850\u03bc\u00b7L<\/span>-1<\/sup>\u65f6L<\/span>1210<\/sub>\u7ec6\u80de\u88ab\u5b8c\u5168\u6291\u5236\u800c\u6b63\u5e38\u7ec6\u80deNIH-3T3\u4e0d\u53d7\u5f71\u54cd\uff0c\u6b64\u6d3b\u6027\u6210\u5206\u53ef\u80fd\u662f\u5c0f\u5206\u5b50<\/span>\uff3b15\uff3d<\/sup>\u3002 <\/span><\/p>\n

\u6bb7\u4e3d\u660e\u7b49(1988)\u5bf9\u9752\u5c9b\u6cbf\u6d77\u5e38\u89c1\u6d77\u85fb\u6297\u80bf\u7624\u6d3b\u6027\u7814\u7a76\u53d1\u73b0\uff1a\u7ea2\u85fb\u95e8\u7684\u6d77\u841d(Gloipeliis furcata)\u3001\u6d77\u5934\u7ea2(Plocamium telfairiae)\u3001\u8708\u86a3\u85fb(Grateloupia filicina)\u3001\u6c5f\u84e0(Gracilaria vervucosa)\u3001\u8f6f\u9aa8\u85fb(Chondria sp.)\u7684\u6c34\u63d0\u53d6\u7ec4\u5206\u5728\u4f53\u5916\u6291\u7624\u8bd5\u9a8c\u4e2d\u5bf9\u7624\u7ec6\u80de\u6709\u76f4\u63a5\u6291\u5236\u4f5c\u7528\uff0c\u5176\u4e2d\u6d77\u5934\u7ea2\u80fd\u6709\u6548\u5730\u6291\u5236S<\/span>180<\/sub>\u548cHeLa\u7ec6\u80de\u3002\u7eff\u85fb\u95e8\u7684\u523a\u677e\u85fb(Codium fragile)\u5728\u7f8e\u5170\u6cd5\u8bd5\u9a8c\u4e2d\u5bf9S<\/span>180<\/sub>\u7ec6\u80de\u6709\u6291\u5236\u4f5c\u7528<\/span>\uff3b16\uff3d<\/sup>\u3002 <\/span><\/p>\n

Mizukoshi\u53d1\u73b029\u79cd\u6d77\u85fb\u7684\u6c34\u6eb6\u6027\u7ec4\u5206\u5177\u6709\u5f88\u5f3a\u7684\u836f\u5b66\u6d3b\u6027\uff0c3\u79cd\u63d0\u53d6\u7269\u5bf9\u5c0f\u9f20\u76ae\u4e0b\u79fb\u690d\u7684B<\/span>16<\/sub>\u9ed1\u8272\u7d20\u7624\u6709\u6291\u5236\u4f5c\u7528\uff0c1\u79cd\u63d0\u53d6\u7269Amphiroa aberrans\u6709\u9ad8\u8fbe77.4%\u7684\u6291\u5236\u7387\u3002\u5c55\u679d\u9a6c\u5c3e\u85fb(Sargassum patens)\u3001\u9a6c\u5c3e\u85fb(S. micracanthum)\u3001\u77f3\u82b1\u83dc(Gelidium amansii)\u3001\u80f6\u76ae\u85fb(Gloiophloea okamurai)\u548c\u6d77\u841d(G. furcata)\u5747\u80fd\u8bf1\u5bfc\u6297\u80bf\u7624\u56e0\u5b50\u7684\u5f62\u6210<\/span>\uff3b17\uff3d<\/sup>\u3002 <\/span><\/p>\n

\u6d77\u5934\u7ea2(Plocamium hamatum)\u4e2d\u5206\u79bb\u51fa\u4e00\u7cfb\u5217\u591a\u5364\u5316\u5355\u8d34\u5316\u5408\u7269\uff0c\u5176\u4e2d\u590d\u5408\u72696\u5177\u6709\u4e2d\u5ea6\u7ec6\u80de\u6bd2\u6d3b\u6027\uff0c\u590d\u5408\u72694\u5177\u6709\u4e2d\u5ea6\u7684\u6297\u7ed3\u6838\u75c5\u548c\u7ec6\u80de\u6bd2\u6d3b\u6027<\/span>\uff3b18\uff3d<\/sup>\u3002\u4ece\u4e73\u8282\u85fb(Galaxaura marginata)\u4e2d\u5206\u79bb\u51fa7\u4e2a\u753e\u9187\u7c7b\u5316\u5408\u7269\uff0c\u5176\u4e2d3\u4e2a\u662f\u7b2c1\u6b21\u5206\u79bb\u51fa\u6765\u7684\u5929\u7136\u4ea7\u7269\uff0c\u5e76\u5bf9\u591a\u79cd\u80bf\u7624\u7ec6\u80de\u6709\u5f88\u5f3a\u7684\u7ec6\u80de\u6bd2\u6027<\/span>\uff3b19\uff3d<\/sup>\u3002\u4ece\u51f9\u9876\u85fb(L.majuscula)\u4e2d\u5206\u79bb\u51fa7\u79cd\u65b0\u7684\u500d\u534a\u841c\uff0c\u5176\u4e2d\u8fc7\u6c27\u5316\u7269Majapolene A\u5728NCl\u7b5b\u9009\u4e2d\u5177\u6709\u5bf9HL<\/span>60<\/sub>\u7ec6\u80de\u7cfb\u7684\u4e2d\u5ea6\u7ec6\u80de\u6bd2\u6d3b\u6027<\/span>\uff3b20\uff3d<\/sup>\u3002 <\/span><\/p>\n

Halomon(\u56fe6)\u662f\u4ece\u677e\u9999\u85fb(Portieria hornemannii)\u4e2d\u63d0\u53d6\u7684\u591a\u5364\u5316\u5355\u8d34\u5316\u5408\u7269\uff0c\u4ece\u4e0d\u540c\u4ea7\u5730\u7684P.hornemannii\u4e2d\u5df2\u53d1\u73b0Halomo\u7c7b\u4f3c\u726910\u591a\u4e2a\u3002\u5176\u5bf9\u80bf\u7624\u5177\u6709\u9009\u62e9\u6027\u6d3b\u6027\uff0c\u5982\u5bf9\u9ed1\u8272\u7d20\u7624\u3001P<\/span>388<\/sub>\u548cL<\/span>1210<\/sub>\u7684IC<\/span>50<\/sub>\u4ec5\u4e3a\u8111\u80bf\u7624\u3001\u80be\u80bf\u7624\u548c\u514b\u9686\u80bf\u7624\u76840.001\u3002\u836f\u7406\u7814\u7a76\u8868\u660e\u8be5\u5316\u5408\u7269\u5177\u6709\u72ec\u7279\u7684\u4f5c\u7528\u673a\u5236\uff0c\u53c2\u4e0e\u5c0f\u9f20\u53ca\u4eba\u7684\u809d\u7ec6\u80de\u8272\u7d20P<\/span>450<\/sub>\u9176\u7684\u4ee3\u8c22\uff0c\u800c\u4e14\u5bf9\u901a\u5e38\u4e0d\u654f\u611f\u7684\u764c\u7ec6\u80de\u7cfb\u5177\u6709\u9009\u62e9\u6027\u6d3b\u6027<\/span>\uff3b21\uff3d<\/sup>\u3002\u5b83\u662fBoyd\u5c0f\u7ec4\u4e8e1992\u5e74\u9996\u6b21\u5206\u79bb\u7684\u6297\u80bf\u7624\u6210\u5206\uff0c\u76ee\u524d\u5df2\u8fdb\u5165\u4e34\u5e8a\u524d\u836f\u7406\u8bc4\u4f30\u9636\u6bb5<\/span>\uff3b22\u300123\uff3d<\/sup><\/p>\n

\"151906\"<\/a> Fig 6\u3000Halomon<\/p>\n

\u8910\u85fb\u4e2d\u7684\u4e3b\u8981\u6297\u80bf\u7624\u6210\u5206\u4e3a\u8910\u85fb\u805a\u7cd6\u3002\u9f20\u5c3e\u85fb(S.thunbergii)\u7684\u591a\u805a\u7cd6\u7ec4\u5206GIV-A(\u03b125<\/sup>D<\/sub>\uff1d127)\uff0c\u572820mg\u00b7kg-1<\/sup>.d-1<\/sup>)\u7684\u5242\u91cf\u65f6\u5728\u4f53\u5185\u5bf9Ehrlich\u8179\u6c34\u7624\u7684\u6709\u9009\u62e9\u6027\u6291\u5236\u6d3b\u6027\u3002GIV-A\u53ef\u80fd\u542bL-\u5ca9\u85fb\u805a\u7cd6\uff0c\u5b83\u662f\u4ee5\u4e00\u79cd\u6240\u8c13\u7f51\u72b6\u5185\u76ae\u7cfb\u7edf\u6fc0\u6d3b\u5242\u800c\u8d77\u4f5c\u7528\u7684\uff0c\u80fd\u52a0\u5f3a\u5de8\u55dc\u7ec6\u80de\u7684\u541e\u566c\u4f5c\u7528\u548c\u5316\u5b66\u53d1\u5149\u4f5c\u7528\u3002\u8fd9\u8868\u660e\u5ca9\u85fb\u805a\u7cd6\u7684\u6297\u80bf\u7624\u4f5c\u7528\u53ef\u80fd\u548c\u52a0\u5f3a\u673a\u4f53\u514d\u75ab\u4f5c\u7528\u76f8\u5173\u7684\uff3b24\uff3d<\/sup>\u3002\u88c2\u53f6\u9a6c\u5c3e\u85fb(S.siliquastrum)\u7684\u6c34\u63d0\u7269\u5bf9\u5c0f\u9f20S180<\/sub>\u8179\u6c34\u7624\u548c\u5b9e\u4f53\u7624\u5177\u6709\u6291\u5236\u6d3b\u6027\u3002\u94dc\u85fb(S.horneri)\u3001\u9a6c\u5c3e\u85fb(S.tortile),\u534a\u53f6\u9a6c\u5c3e\u85fb(S.hemiphyllum)\u7684\u591a\u7cd6\u7ec4\u5206\u3001\u7cd6\u86cb\u767d\u7ec4\u5206\u548c\u4f4e\u5206\u5b50\u6210\u5206\u5728\u4f53\u5185\u5bf9S180<\/sub>\u548cEhrlich\u8179\u6c34\u7624\u90fd\u6709\u6291\u7624\u6d3b\u6027\u3002\u9f20\u5c3e\u85fb(S.thunbergii)\u7684\u6c34\u63d0\u7269\u5bf9S180<\/sub>\u5b9e\u4f53\u7624\u7684\u6291\u7624\u7387\u4e3a31.5%\uff3b16\uff3d<\/sup>\u3002<\/p>\n

 <\/p>\n

\u5fae\u52b3\u9a6c\u5c3e\u85fb(Sargassum fulvellum)\u4e2d\u63d0\u53d6\u7684\u8910\u85fb\u9178\u94a0\u80fd\u6291\u5236\u79fb\u690d\u7684\u5c0f\u9f20S180<\/sub>\u8089\u7624\u7ec6\u80de\u3002Yamamoto(1985)\u53d1\u73b0\u542b\u6709\u4f4e\u542b\u91cf\u786b\u9178\u916f\u7684\u8910\u85fb\u9178\u94a0\u80fd\u6291\u5236\u75311\uff0c2-\u4e8c\u7532\u80bc\u8bf1\u53d8\u5f15\u8d77\u7684\u5927\u9f20\u5c0f\u80a0\u764c\u7684\u53d1\u751f\uff3b25\uff3d<\/sup>\u3002\u65e5\u672c\u53ef\u98df\u6027\u8910\u85fb\u805a\u7cd6\u80fd\u6709\u6548\u7684\u6291\u5236L1210<\/sub>\u767d\u8840\u75c5\u7ec6\u80de\u548c\u5c0f\u9f20S180<\/sub>\u8089\u7624\u7ec6\u80de\u7684\u751f\u957f\u3002\u4ece\u8910\u85fb\uff08Ascophyllum nodosum\uff09\u63d0\u53d6\u7684\u4f4e\u5206\u5b50\u91cf\u7684\u8910\u85fb\u7cd6\u80f6\u5bf9CL39<\/sub>\u6210\u7ea4\u7ef4\u7ec6\u80de\u548c\u817a\u764c\u514b\u9686\u682aColo320DM\u7684\u6291\u5236\u7387\u5206\u522b\u4e3a85%\u548c50%\uff0c\u5176\u6d3b\u6027\u6d53\u5ea6\u5206\u522b\u4e3a10\u03bcg\u00b7L-1<\/sup>\u548c100\u03bcg\u00b7L-1<\/sup>\u3002<\/p>\n

Mayer\u7b49(1987)\u5bf9Argentina\u5357\u6d77\u5cb8\u6d77\u85fb\u8fdb\u884c\u4e86\u836f\u7269\u7b5b\u9009\uff0c\u8bc1\u660e\u5de8\u85fb(Macrocystis pyrifera)\u7684\u7532\u9187\u7c97\u63d0\u7269\u5bf9\u5c0f\u9f20\u7684\u5feb\u901f\u751f\u957f\u7684P388<\/sub>\u6dcb\u5df4\u767d\u7ec6\u80de\u548cEhrlich\u764c\u7ec6\u80de\u7cfb\u6709\u6297\u80bf\u7624\u6d3b\u6027\uff0c\u5e76\u5bf9\u5c0f\u9f20P388<\/sub>\u7ec6\u80de\u548c\u4ebaKB\u7ec6\u80de\u6709\u7ec6\u80de\u6bd2\u6d3b\u6027\u3002\u4f46\u5206\u79bb\u7eaf\u5316\u540e\u7684\u8910\u85fb\u805a\u7cd6\u3001\u8910\u85fb\u9178\u94a0\u548c\u6606\u5e03\u591a\u7cd6\u90fd\u4e0d\u5177\u6709\u6297\u80bf\u7624\u6d3b\u6027\uff3b26\uff3d<\/sup>\u3002<\/p>\n

Numata\u7b49(1991)\u5bf921\u79cd\u5927\u578b\u6d77\u85fb\u7279\u5b9a\u7ec4\u5206\u7684\u7ec6\u80de\u6bd2\u5b9e\u9a8c\u7814\u7a76\u8868\u660e\uff0c\u9a6c\u5c3e\u85fb\uff08S.tortile\u7684\u7532\u9187\u63d0\u53d6\u7269\u7684\u6c2f\u4eff\u7ec4\u5206\u5bf9\u57f9\u517b\u7684P388<\/sub>\u6dcb\u5df4\u767d\u8840\u75c5\u7ec6\u80de\u6709\u8f83\u5927\u7684\u6d3b\u6027\u3002\u5176\u4e2d\u542b\u6709\u4e8c\u7f9f\u9a6c\u5c3e\u85fb\u918c(Dihydroxysargaquinone)\u548c\u9a6c\u5c3e\u85fb\u841c\u9187(Sargatriol)\uff0c\u524d\u8005\u662f\u4e3b\u8981\u7684\u7ec6\u80de\u6bd2\u6210\u5206\uff0c\u540e\u8005\u4e5f\u5177\u6709\u4e2d\u5ea6\u7684\u6d3b\u6027\uff0c\u9f20\u5c3e\u85fb(S. thunbergii)\u7532\u9187\u63d0\u53d6\u7269\u7684\u6c2f\u4eff\u7ec4\u5206\u4e5f\u5177\u6709\u8f83\u9ad8\u7684\u6d3b\u6027\uff3b27\uff3d<\/sup>\u3002\u65b0\u897f\u5170\u8910\u85fb\uff08Landsburgia quercifolia\uff09\u5206\u79bb\u51fa\u7684\u8131\u6c27\u62c9\u5e15\u9187(Dexylapachol)\u6709\u6297\u771f\u83cc\u548c\u6297\u80bf\u7624\u4f5c\u7528\uff0c\u5176\u5bf9P388<\/sub>\u767d\u8840\u75c5\u7ec6\u80de\u7684IC50<\/sub>\u4e3a0.6\u03bcg\u00b7L-1<\/sup>\u3002\u4eceLandsburgia quercifolia\u4e2d\u8fd8\u63d0\u53d6\u51fa\u5176\u4ed6\u5316\u5408\u7269\uff0c\u59822-(3-\u7532\u57fa-2-\u4e01\u70ef\u57fa)-2\uff0c3-\u73af\u6c27-1\uff0c4-\u8418\u918c4\uff0c4-\u4e8c\u7532\u57fa\u7f29\u916e\u7b49\uff0c\u80fd\u8f6c\u5316\u4e3a\u8131\u6c27\u62c9\u5e15\u9187\u76842\uff0c3-\u73af\u6c27\u5316\u7269\uff0c\u540c\u6837\u5177\u6709\u6297P388<\/sub>\u767d\u8840\u75c5\u7ec6\u80de\u7684\u529f\u80fd\uff3b28\uff3d<\/sup>\u3002<\/p>\n

Xenicane\u662f\u7f51\u5730\u85fb\u4ea7\u751f\u7684\u7ed3\u6784\u72ec\u7279\u7684\u542b\u6709\u4e2d\u5ea6\u73af\u5f62\u7684\u4e8c\u841c\u5316\u5408\u7269\uff0c\u5b83\u542b\u6709\u4e00\u7c7b\u7531\u73af\u58ec\u70f7\u9aa8\u67b6\u7ec4\u6210\u7684\u590d\u5408\u7269\uff0c\u662f\u5176\u4ed6\u5929\u7136\u4ea7\u7269\u4e2d\u6240\u6ca1\u6709\u7684\u3002\u4ece\u7f51\u5730\u85fbDictyota dichotoma\u4e2d\u5206\u79bb\u51fa\u76844\u79cd\u65b0\u7684Xenicane:4-acetoxydictyolact- one;dictyotalide A;dictyotalide B\u548cnordictyotalide,\u5bf9B16<\/sub>\u5c0f\u9f20\u9ed1\u7d20\u7624\u7ec6\u80de\u90fd\u6709\u4f53\u5916\u6291\u7624\u6d3b\u6027\uff0c\u5176IC50<\/sub>\u5206\u522b\u4e3a1.57mg\u00b7L-1<\/sup>;2.57mg\u00b7L-1<\/sup>;0.58mg\u00b7L-1<\/sup>;1.58mg\u00b7L-1<\/sup>\u3002\u4ece\u53e6\u4e00\u79cd\u7f51\u5730\u85fb\u4e2d\u5206\u79bb\u5f97\u5230\u7684Dolabellane-3\u768416-\u4e8c\u70ef\u884d\u751f\u7269\u5bf9KB\u80bf\u7624\u7ec6\u80de\u6709\u660e\u663e\u7684\u7ec6\u80de\u6bd2\u6d3b\u6027\u3002\u4ece\u539a\u7f18\u85fb(Dilophus lighlatus)\u4e2d\u5206\u79bb\u51fa\u4e00\u79cd\u65b0\u7684Xenicane\u7c7b\u578b\u7684\u4e8c\u841cDilopholide\u548c4\u79cd\u5df2\u77e5\u7684\u841c\u7c7b\u5316\u5408\u7269\uff0c5\u79cd\u590d\u5408\u7269\u5bf9\u54fa\u4e73\u7ec6\u80de\u7624\uff1aKB\u3001P388<\/sub>\u3001\u4eba\u80ba\u764c\u7ec6\u80de(NSCLC-N6)\u3001\u8868\u8fbe\u591a\u79cd\u6297\u836f\u6027\u57fa\u56e0\u7684\u5c0f\u9f20\u767d\u8840\u75c5(P388<\/sub>\/DOX)\u90fd\u5177\u6709\u7ec6\u80de\u6bd2\u6d3b\u6027\uff3b29\uff3d<\/sup>\u3002<\/p>\n

\u677e\u85fb(C.pngniformis)\u7684\u591a\u7cd6\u7ec4\u5206\u3001\u7cd6\u86cb\u767d\u548c\u4f4e\u5206\u5b50\u6210\u5206\u5728\u4f53\u5185\u5bf9S180<\/sub>\u548cEhrlich\u8179\u6c34\u7624\u90fd\u6709\u6291\u7624\u6d3b\u6027\u3002\u523a\u677e\u85fb\uff08C.fragrile\uff09\u548c\u7d2b\u83dc(Porphyra yezoensis)\u7684\u86cb\u767d\u8d28\u591a\u7cd6\u7ec4\u5206\u5bf9S180<\/sub>\u8089\u7624\u7ec6\u80de\u6709\u6297\u80bf\u7624\u548c\u514d\u75ab\u6291\u5236\u4f5c\u7528\u3002\u677e\u85fb\u548c\u7d2b\u83dc\u5728\u6d53\u5ea6\u5206\u522b\u4e3a50mg\u00b7kg-1<\/sup>\u548c50mg\u00b7kg-1<\/sup>\u65f6\u5bf9\u5b9e\u4f53\u7624\u7684\u6291\u5236\u7387\u4e3a53.0%\u548c17.35%\u3002\u6749\u53f6\u8568\u85fb(Caulerpa taxifolia)\u4e3b\u8981\u4ee3\u8c22\u7269\u500d\u534a\u841cCaulerpenyne\u5bf9KB\u7ec6\u80de\u548c\u6210\u7ea4\u7ef4\u7ec6\u80de\u5177\u6709\u7ec6\u80de\u6bd2\u6d3b\u6027\uff0cCaulerpenyne\u5bf98\u79cd\u4eba\u7c7b\u8d77\u6e90\u7684\u80bf\u7624\u7ec6\u80de\u7cfb\u5177\u6709\u751f\u957f\u6291\u5236\u4f5c\u7528\uff0c\u5176\u4e2d\u5bf9\u4e00\u79cd\u514b\u9686\u76f4\u80a0\u764c\u6700\u654f\u611f\uff0c\u5176IC50<\/sub>\u4e3a6.1\uff5e7.7mmol\u00b7L-1\uff3b30\uff3d<\/sup>\u3002<\/p>\n

3\u3000\u7ed3\u8bed<\/strong><\/p>\n

\u6211\u56fd\u5e45\u5458\u8fbd\u9614\uff0c\u85fb\u7c7b\u8d44\u6e90\u4e30\u5bcc\uff0c\u5229\u7528\u85fb\u7c7b\u751f\u4ea7\u6297\u80bf\u7624\u7269\u8d28\u5f88\u6709\u6f5c\u529b\u3002\u636eNCI\u7684\u7814\u7a76\u62a5\u9053\uff0c3.5%\u7684\u6d77\u6d0b\u690d\u7269\u6709\u6297\u80bf\u7624\u6216\u7ec6\u80de\u6bd2\u6d3b\u6027\uff0c\u6709\u7684\u65e2\u6709\u6297\u80bf\u7624\u6d3b\u6027\u4ea6\u5177\u6709\u6297\u75c5\u6bd2\u548c\u514d\u75ab\u8c03\u8282\u4f5c\u7528\u3002\u968f\u7740\u65b0\u75be\u75c5\u7684\u53d1\u73b0\uff0c\u4eba\u4eec\u5fc5\u5c06\u52a0\u5927\u6d77\u6d0b\u836f\u7269\u7814\u7a76\u7684\u529b\u5ea6\uff0c\u53bb\u5f00\u53d1\u65b0\u7684\u7ed3\u6784\u7279\u5f02\u7684\u65b0\u836f\uff3b31\uff3d<\/sup>\u3002\u76ee\u524d\u56fd\u5185\u85fb\u7c7b\u6297\u80bf\u7624\u7684\u62a5\u9053\u76f8\u5bf9\u8f83\u5c11\uff0c\u4e3b\u8981\u6709\u4e2d\u56fd\u533b\u5b66\u79d1\u5b66\u9662\u836f\u7269\u7814\u7a76\u6240\u8c2d\u9510\u7b49\u4ece\u5927\u56e2\u6247\u85fb(Padina crassa Yamada)\u4e2d\u5206\u79bb\u5f97\u5230\u7684\u4e00\u79cd\u5ca9\u85fb\u753e\u9187\uff0c\u7ecf\u6c27\u5316\u8fd8\u539f\u5236\u5907\u5f97\u03b3\u03b1-\u7f9f\u57fa\u5ca9\u85fb\u753e\u9187\u5bf9\u4eba\u65e9\u5e7c\u7c92\u767d\u8840\u75c5\u7ec6\u80deHL60<\/sub>\u6709\u5f88\u5f3a\u7684\u5206\u5316\u8bf1\u5bfc\u6d3b\u6027\uff0c\u80fd\u4f7f\u5b9e\u4f53\u7624\u548c\u767d\u8840\u75c5\u7ec6\u80de\u5206\u5316\u4e3a\u8fd1\u4f3c\u6b63\u5e38\u7ec6\u80de\uff3b32\uff3d<\/sup>\u3002\u4e2d\u5c71\u5927\u5b66\u82cf\u955c\u5a31\u7b49\u4ece\u5357\u6d77\u8033\u58f3\u85fb(Peyssonnelia caulifera)\u4e2d\u5206\u79bb\u7684\u9ad8\u5355\u841c\u7684\u916fCaulilide\u5bf9\u827e\u6c0f\u8179\u6c34\u7624\u53caS180<\/sub>\u80bf\u7624\u7ec6\u80de\u7684IC50<\/sub>\u5206\u522b\u4e3a2.4g\u00b7L-1<\/sup>\u548c0.5g\u00b7L-1\uff3b33\uff3d<\/sup>\u3002\u4e2d\u79d1\u9662\u6d77\u6d0b\u6240\u79e6\u677e\u7b49\u5c06\u6297\u80bf\u7624\u7684\u522b\u85fb\u5170\u86cb\u767d\u57fa\u56e0\u8f6c\u5230\u5927\u80a0\u6746\u83cc\u4e2d\uff0c\u8fd0\u7528\u5fae\u751f\u7269\u53d1\u9175\u6280\u672f\u9ad8\u6548\u8868\u8fbe\uff0c\u53d6\u5f97\u4e86\u5f88\u597d\u7684\u6548\u679c\uff3b34\uff3d<\/sup>\u3002\u4e3a\u8fce\u5934\u8d76\u4e0a\u4e16\u754c\u5148\u8fdb\u6c34\u5e73\uff0c\u6709\u6548\u7684\u5f00\u53d1\u5229\u7528\u6211\u56fd\u4e30\u5bcc\u7684\u85fb\u7c7b\u8d44\u6e90\uff0c\u6211\u4eec\u5e94\u7740\u624b\u4ece\u4ee5\u4e0b\u4e09\u4e2a\u65b9\u9762\u53d1\u5c55\uff1a\uff081\uff09\u3000\u5927\u529b\u5f00\u53d1\u85fb\u7c7b\u6297\u80bf\u7624\u8d44\u6e90\u3002\u76ee\u524d\u6211\u56fd\u5229\u7528\u9ad8\u901a\u91cf\u7b5b\u9009\u6280\u672f\u8fdb\u884c\u6297\u80bf\u7624\u7684\u7b5b\u9009\u8f83\u5c11\uff0c\u4e3a\u4e86\u66f4\u6709\u6548\u5730\u5229\u7528\u5145\u8db3\u7684\u85fb\u7c7b\u8d44\u6e90\uff0c\u5b9e\u73b0\u6d77\u6d0b\u53ca\u9646\u5730\u85fb\u7c7b\u8d44\u6e90\u7684\u6709\u6548\u5229\u7528\uff0c\u5b9e\u73b0\u4f18\u4e2d\u9009\u4f18\uff0c\u66f4\u5feb\u66f4\u597d\u5730\u7814\u5236\u51fa\u6709\u76ca\u4e8e\u4eba\u6c11\u5065\u5eb7\u7684\u836f\u7269\u3002\u6211\u4eec\u5e94\u8be5\u7cfb\u7edf\u6536\u96c6\u4e2d\u56fd\u6cbf\u6d77\u53ca\u6de1\u6c34\u85fb\u7c7b\u5e76\u8fdb\u884c\u6297\u80bf\u7624\u7b5b\u9009\uff0c\u5efa\u7acb\u4e2d\u56fd\u85fb\u7c7b\u836f\u7269\u8d44\u6e90\u79cd\u8d28\u5e93\uff0c\u540c\u65f6\u8fd0\u7528\u73b0\u4ee3\u5316\u7684\u5206\u79bb\u7eaf\u5316\u6280\u672f\u548c\u9ad8\u901a\u91cf\u7684\u7b5b\u9009\u6280\u672f\u8fdb\u884c\u6709\u9488\u5bf9\u6027\u7684\u7814\u7a76\u3002\uff082\uff09\u3000\u4efb\u4f55\u836f\u7269\u7684\u6709\u6548\u7814\u7a76\u5f00\u53d1\u90fd\u4e0e\u5176\u6765\u6e90\u7684\u5145\u5206\u6027\u6709\u5173\u7684\uff0c\u6297\u80bf\u7624\u836f\u7269\u7684\u7814\u7a76\u4e5f\u5fc5\u987b\u5145\u5206\u8003\u8651\u5230\u539f\u6599\u95ee\u9898\uff0c\u6240\u4ee5\u6297\u80bf\u7624\u836f\u7269\u7814\u7a76\u5e94\u8be5\u4e0e\u85fb\u7c7b\u751f\u7269\u5de5\u7a0b\u76f8\u7ed3\u5408\u3002\u4e00\u65b9\u9762\u8fd0\u7528\u7ec6\u80de\u5de5\u7a0b\u3001\u751f\u7269\u53cd\u5e94\u5668\u7b49\u6280\u672f\u89e3\u51b3\u542b\u6297\u80bf\u7624\u7269\u8d28\u85fb\u7c7b\u7684\u57f9\u517b\u95ee\u9898\uff0c\u53e6\u4e00\u65b9\u9762\u8bbe\u6cd5\u8fd0\u7528\u57fa\u56e0\u5de5\u7a0b\u5728\u5176\u5b83\u751f\u7269\u4f53\u5185\u9ad8\u6548\u8868\u8fbe\u6297\u80bf\u7624\u7269\u8d28\u3002\uff083\uff09\u3000\u52a0\u5f3a\u56fd\u9645\u5408\u4f5c\uff0c\u79ef\u6781\u5f15\u8fdb\u56fd\u5916\u5148\u8fdb\u6280\u672f\uff0c\u52a0\u5f3a\u57fa\u7840\u7814\u7a76\uff0c\u53d1\u73b0\u5177\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u7684\u5148\u5bfc\u5316\u5408\u7269\uff0c\u540c\u65f6\u4ee5\u6700\u5feb\u7684\u901f\u5ea6\u5f00\u53d1\u65b0\u7684\u4ea7\u54c1\uff0c\u5982\u6297\u80bf\u7624\u4e2d\u6210\u836f\u7684\u5f00\u53d1\u3002<\/p>\n

 <\/p>\n

\u53c2\u8003\u6587\u732e<\/strong><\/p>\n

1\uff0cNekhoroshev MV, Vorornova OK. The Black Sea algae are potential source of terapevtic antitumor drugs. Al’-gologiya,1996,6(1):86\uff5e90<\/p>\n

2\uff0cGuven KC. Unlu S, Blige N et al. Cytost atic activity of marine algae. Pharmazie, 1995,50(5):369\uff5e370<\/p>\n

3\uff0cPatterson GML, Baldwin CL, Bplis CM\uff0cet al. Antineoplastic activity of cultured blue-green algae (Cyanophyta). J Phycol, 1991,27:530\uff5e536<\/p>\n

4\uff0cPatterson GML, Larsen LK & Moore RE. Bioactive natural products from blue-green algae. J Appl Phycol, 1994,6:151\uff5e157<\/p>\n

5\uff0cSmith CD, Carmeli S, Moore RE\uff0cet al. Scytophycins, novel microfilament-depolymerizing a gents which circumvent P-glycoprotein-mediated multidrug resistance. Cancer Res, 1993,15,53(6):1343\uff5e1347.<\/p>\n

6\uff0cJung JH, Moore RE, Patterson GML. Scytophycins from a blue-green alga belonging to the nostocaceae. Phytochemistry, 1991,30(11):3615\uff5e3616.<\/p>\n

7\uff0cPatterson GML, Smith CD, Kimura LH\uff0cet al. Action of tolytoxin on cell morphology, cytoskeletal organization, and action polymerization. Cell Motility Cytoskeleton, 1993,24:39\uff5e48<\/p>\n

8\uff0cLuesch H, Yoshida WY, Moore RE\uff0cet al. Lyngbyastatin 2 and norlyngbyastatin 2, analogues of dolastatin G and nordolastatin G from the marine cyanobacterium Lyngbya majuscula. J N at Prood, 1999,62(12):1702\uff5e1706<\/p>\n

9\uff0cGerwick WH, Roberts MA, Proteau PJ\uff0cet al. Screening cultured marine microalgae for anticancer-type activity. J Appl Phycol, 1994,6:143\uff5e149<\/p>\n

10\uff0cTrimurtulu G, Ohtani I, Patterson GML et al. Total structures of cryptophycins, potent ant itumor depsipeptides from the blue-green alga N ostoc sp. strain GSV 224. J Am Chem\u3000Soc, 1994,116(11):4729\uff5e4737.<\/p>\n

11\uff0cPanda D, Himes RH, Moore R\uff0cet al. Me chanism of action of the unusually potent micro tubule inhibitor cryptophycin 1. Biochemistry, 1997,36(42):12948\uff5e12953.<\/p>\n

12\uff0cKoike K, Sato S, Yamaji M\uff0cet al. Occurrence of okadaic acid-producing Prorocentrum lima on the Sanriku coast, northern Japan. Toxicon, 1998,36(12):2039\uff5e2042.<\/p>\n

13\uff0cScheuer PJ. Some marine ecological pheno mena: Chemical basis and biomedical potential. Science,1990,248:173\uff5e177.<\/p>\n

14\uff0cLiu Zhaoqian, Cui Changhai, Zhang Youmin. Stuies of the effect on tumor and normal cells in virtro with bioactive materials isolated from algae by a microcalorimetric method. J Biochem Biophys Methods,1991,23(2):163\uff5e167.<\/p>\n

15\uff0cHarada H, Noro T, Kamei Y. Selective antitumor activity in vitro from marine algae from Japan coast. Biol Pharm Bull, 1997,20(5):541\uff5e546.<\/p>\n

16\uff0c\u6bb7\u4e3d\u660e\uff0c\u9b4f\u4e91\u8389\uff0c\u4e01\u4f1f\uff0c\u7b49.\u9752\u5c9b\u6cbf\u6d77\u5e38\u89c1\u6d77\u85fb\u6297\u80bf\u7624\u53ca\u6297\u83cc\u6d3b\u6027\u521d\u62a5.\u4e2d\u56fd\u6d77\u6d0b\u836f\u7269\uff0c1988\uff0c7\uff081\u30012\uff09\uff1a39\uff5e41.<\/p>\n

17\uff0cMizukoshi S,Matsuoka H, Katou H et al. Search for bioactive substances from marine algae. Bull Fac Bioresour Mie Univ Miedai Seibutsushigen Kiyo, 1992,8:27\uff5e34.<\/p>\n

18\uff0cKonig GM, Wright AD, Linden A Plocamium hamatum and its monoterpenes: chemical and biological investigations of the tropical marine red alga. Phytochemistry, 1999,52(6):1047\uff5e1053<\/p>\n

19\uff0cSheu JH, Huang SY, Wang GH\uff0cet al. Study on cytotoxic oxygenated desmosterols isolated from the red alga Galaxaura marginata\uff0eJ Nat Prod, 1997,60(9):900\uff5e903.<\/p>\n

20\uff0cErickson KL, Beutler JA, Gray GN\uff0cet al. Majapolene A, a cytotoxic peroxide, and related sesquiterpenes from the red alga Laurencia majuscula. J Nat Prod, 1995,58(12):1848\uff5e1860.<\/p>\n

21\uff0cFuller RW, Cardellina JH, Kato Y\uff0cet al. A pentahalogenated monoterpene from the red alga Portiera hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines. J Med Chem, 1992,35(16):3007\uff5e3011.<\/p>\n

22\uff0cEgorin MJ, Rosen DM, Benjamin SE\uff0c et al. In vitro metabolism by mouse and human liver preparations of halomon, an antitumor halogenated monoterpene. Cancer Chemother Pharmacol, 1997,41(1):9\uff5e14.<\/p>\n

23\uff0cFuller RW, Cardellina JH, Jurek J\uff0cet al. Isolation and structure\/activity features of halomon-related antitumor monoterpenes from the red alga Portieria hornemannii. J Med Chem\uff0c 1994,37(25):4407\uff5e4411.<\/p>\n

24\uff0cItoch H, Noda H, Amano H\uff0cet al. Antitumor activity and immunological properties of marine algae polysaccharides, ecpecially fuoidan, prepareed from Sargassum thunbergii of Phaeophyceae. Anticancer Res., 1993,13(6A):2045\uff5e2052.<\/p>\n

25\uff0cYamamoto I\uff0cMaruyama H. Effect of dietary seaweed prepation on 1,2-dimethylhydrazine-induced intestinal carcinogenesis in rats. Canc Lett, 1985,26:241\uff5e251.<\/p>\n

26\uff0cMayer AMS, Liliana K, Daniel RB. Biological activity in Macrocystis pyrifera from Argentina: sodium alginate, fucoidan and laminaran\uff08I\uff09 Antitumor, cytotoxicity and humoral immune response. Hydrobiologia,1987,151\u3001152:483\uff5e489.<\/p>\n

27\uff0cNumata A, Kanbara S, Takahashi C\uff0cet al. Cytotoxic activity of marine algae and a cytotoxic principle of the brown alga Sargassum tortile. Chem Pharm Bull Tokyo, 1991,39(8):2129\uff5e2131.<\/p>\n

28\uff0cPerry NB, Blunt JW, Munro MHG\uff0cet al. A cytotoxic and antifungial 1,4-naphthoquinone and related compounds from a New Zealand brown alga. Landsburgia quercifolia. J Nat Prod, 1991,54(4):978\uff5e985.<\/p>\n

29\uff0cBouaicha N, Pesando D, Puel D\uff0cet al. Cytotoxic diterpenoids from the brown alga Dilophus ligulatus. J Nat Prod\uff0c1993,56(10):1747\uff5e1752.<\/p>\n

30\uff0cFischel JL, Lemee R, Formento P\uff0cet al. Cell growth inhibitory effects of caulerpenyne, a sesquiterpenoid from the marine alga Caulerpa taxifolia. Anticancer Res, 1995,15(5B):2155\uff5e2160.<\/p>\n

31\uff0c\u8303\u6653\uff0c\u4e25\u5c0f\u519b\uff0c\u675c\u51a0\u534e\uff0c\u7b49.\u56fd\u5916\u6d77\u6d0b\u836f\u7269\u7814\u7a76\u524d\u6cbf\u4e0e\u6211\u56fd\u7684\u53d1\u5c55\u6218\u7565.\u4e2d\u56fd\u6d77\u6d0b\u836f\u7269\uff0c1999\uff0c18(2)\uff1a42\uff5e45.<\/p>\n

32\uff0c\u8c2d\u9510\uff0c\u5218\u7ea2\u5ca9\uff0c\u97e9\u9510\uff0c\u7b49.\u56e2\u6247\u85fb\u4e2d\u4e00\u79cd\u65b0\u578b\u7684\u5206\u5316\u8bf1\u5bfc\u52427-\u7f9f\u57fa\u5ca9\u85fb\u753e\u9187.\u4e2d\u56fd\u6d77\u6d0b\u836f\u7269\uff0c1992\uff0c(3)\uff1a4\uff5e5.<\/p>\n

33\uff0c\u82cf\u955c\u5a31\uff0c\u6768\u5c0f\u53cc.\u8033\u58f3\u85fbPeyssonnelia cauliferaz\u4e2d\u6297\u80bf\u7624\u6709\u6548\u6210\u5206\u7814\u7a76.\u4e2d\u56fd\u6d77\u6d0b\u836f\u7269\uff0c1992\uff0c11(3)\uff1a1\uff5e3.<\/p>\n

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